Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice

Abstract Mitochondrial fusion and fission, which are strongly related to normal mitochondrial function, referred as dynamics. defects in the liver cause a non-alcoholic steatohepatitis-like phenotype cancer. However, whether fission defect directly impair function stimulate disease progression, too, is unclear. Dynamin-related protein 1 (DRP1) key factor controlling fission. We hypothesized that DRP1 causal involved development progression. Drp1 promoted endoplasmic reticulum (ER) stress, hepatocyte death, subsequently induced infiltration of inflammatory macrophages. deletion increased expression numerous genes immune response DNA damage LiKO mouse primary hepatocytes. administered lipopolysaccharide (LPS) liver-specific -knockout ( LiKO) mice observed an cytokine serum caused by exaggerated ER stress enhanced inflammasome activation. This study indicates defect-induced dynamics dysfunction regulates fate hepatocytes enhances LPS-induced acute injury vivo.